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That changed after chemist Bruce Merrifield developed solid-phase peptide synthesis, a breakthrough that earned him the Nobel Prize in 1984 and dramatically simplified production of these fragile biomolecules by allowing them to be built much more efficiently compared to purification

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Animal models show it affects angiogenesis, collagen organization, and growth factor modulation

The Sucrosomial B12 formulation possibly overcomes these obstacles by entrapping vitamin B12 within a protective matrix composed of phospholipids, primarily derived from sunflower lecithin, and a sucrester (sucrose ester)