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Furthermore, zonulin was already increased in two independent cohorts in a subset of patients with RA-specific autoimmunity that had not yet developed the disease (pre-RA) (Fig

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Nonetheless, individuals with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN2) should discuss this with their clinician before enrolling in any trial involving this class of agent

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