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Zepbound works by increasing insulin production and decreasing glucagon production when blood sugar levels are high

Mice with Gstm1 gene deletion have a modest elevation of baseline blood pressure and increased urinary levels of 8-isoprostane, a marker of oxidative stress

Common gastrointestinal side effects include nausea, diarrhoea, constipation, and abdominal pain, typically emerging during treatment initiation or dose escalation

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Taking metformin with or after food, using gradual dose increases, and considering the modified-release formulation can significantly reduce these symptoms whilst maintaining effective blood glucose control

Kunze T (1996)