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A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007
Although raised homocysteine levels might be partly due to a poor vitamin B 12 status, the latter was not related to risk of dementia or Alzheimer's disease in this study (73)
You just have to know when youre working from robust human data, versus extrapolating from mouse models
Who Should Avoid MIC B12 and Provider Screening Contraindications include known allergy to methionine, inositol, choline, or cyanocobalamin
Their team evaluates your health goals, metabolism, and lifestyle to create a tailored plan that helps maximize fat loss, boost energy, and support long-term results
What You Need to Know Harvard Health Publishing: The A List for Vitamin B-12 Sources National Institutes of Health Office of Dietary Supplements: Vitamin B12 Grant Chu, MD, MS, MBA, FACP Medical Reviewer Grant Chu, MD, is an associate clinical professor at the David Geffen School of Medicine at UCLA
