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Despus de monitorear los niveles de glucosa en sangre de John y discutir cualquier efecto secundario potencial, el mdico aumenta gradualmente la dosis hasta alcanzar el control de glucosa deseado con efectos secundarios mnimos

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Starting with 2 mg per week, moving to 4 mg, and then 8 mg weekly for most of the study 5

Subsequently, d-allulose (1 or 3 g kg 1 ) or saline was administered p.o., urine was collected and volume measured over 24 h