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Cryo-electron microscopy studies (Li et al., 2024, Cell Discovery) revealed the peptide adopts a single continuous helix achieving balanced activation through conserved interactions and receptor-specific transmembrane domain contacts

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Oxidative stress induces the expression of Trx [165, 166], which is believed to protect against oxidative stress by (a) modulating signal transduction properties of ROS [167, 168], (b) scavenging radicals [169], (c) reducing intracellular disulfides, (d) selectively modulating the DNA-binding of transcription factors like AP-1 [170, 171] and NF-kB [172], (e) preventing apoptosis by binding to apoptosis signal-regulating kinase 1 (ASK-1) [173], (f) donating electrons to periredoxins, which are involved in the reduction of peroxides [174, 175], (g) reactivating partially oxidized and inactivated recombinant TTase [148], and (h) selectively inducing several antioxidant gene expressions [176]