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Anakinra, a recombinant human antagonist of IL-1 (blocking both IL-1 and IL-1) and lutikizumab (a dual-variable-domain IL 1/1 antagonist) have shown some promise for the treatment of HS (13, 60)
These protein-based tools allow real-time, reversible monitoring of the glutathione redox potential (E_GSH) within living cells, offering subcellular resolution that chemical probes cannot match
GLP-1 therapy works best when the full metabolic picture is tracked
This statement can also be extended to the role of the GLP1-like drugs used for diabetes treatment, targeted to these different types of insulin-producing cells
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