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Undeniably, Ca 2+ fluxes are crucial for almost all reported RCD pathways in erythrocytes, whereas in apoptosis, Ca 2+ elevation mediates primarily the mitochondrial outer membrane permeabilization (MOMP), triggering the intrinsic apoptosis [192]

257,258,259,260 Microglia-derived TNF-, for example inhibits viral replication in astrocytes, 259 while microglial IL-6 reduces neuronal death

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Its mechanism involves recruiting immune cells to injury sites and promoting angiogenesis, making it a valuable component in regenerative medicine

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