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Preclinical research in animal models has identified GLP-1 receptors in synovial tissue, cartilage, and bone, suggesting potential for direct effects on joint structures

While this approach was useful for developing an overarching view of the landscape of intervention research, it was also subject to biases and limitations

Patients with diabetes, obesity, and existing atherosclerotic cardiovascular disease stand to benefit the most.

however, some have limited experience in certain levels of liver impairment and therefore caution in use may need to be exercised

Can flag anemia, infection, or inflammation that might affect tolerance or dosing