Therapeutic targets of oxidative/nitrosative stress and neuroinflammation in ischemic stroke: applications for natural product efficacy with omics and systemic biology
Results announced in December 2025 confirmed the Phase 2 findings at a longer timepoint (Lilly Press Release, Dec 2025): The 28.7% weight loss at 68 weeks exceeds both semaglutide (~15% in STEP trials) and tirzepatide (~22.5% in SURMOUNT trials) at similar timepoints
"Anxiety about when and where symptoms will occur can also lead to avoidance of social activities, especially ones in which food is the focus, or when bathrooms may not be readily available
Cui H, Wang N, Li H, Bian Y, Wen W, Kong X, et al
others had modest effects on weight loss
Unfortunately, these warnings may fall short of alerting patients and doctors to the full extent of the risks associated with this drug