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The exponential error model or additive error model was used for assessing the inter-study variability, which is shown in formulas (dg): where 1, i and 2, i represent the variabilities of inter-study, which are added into E max or ET 50 when available and they are assumed to be distributed normally and the distribution characteristics are a mean of 0 and variance of 1, i 2 and 2, i 2 , respectively

35 Alternatively, reporting of neurochemical levels relative to a reference neurochemical in the same voxel is a common approach, as measurements are technologically uncomplicated (only a single spectrum must be collected) and no correction for partial-volume effects is required

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Studies have explored these peptides in endocrine and metabolism focused experimental models

The reduction of cell growth and viability showed in TC cells were due to the regulation by metformin of the AMPK-mTOR pathway, inhibiting cell cycle progression and inducing apoptosis (Klubo-Gwiezdzinska et al., 2012

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