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A strategy for fusion expression and preparation of functional glucagon-like peptide-1 (GLP-1) analogue by introducing an enterokinase cleavage site

Clinical complications, such as liver cirrhosis, hepatocellular carcinoma, diabetes, cardiomyopathy, hypogonadism, arthropathy, and osteoporosis, may occur [65]

10.1186/s13287-015-0192-0 4 Alcayaga-MirandaF.CuencaJ.Luz-CrawfordP.Aguila-DazC.FernandezA.FigueroaF

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Tumor risk via p53 pathway interference Mitigate risk by: Careful patient selection: exclude patients with pre-existing active malignancy or high tumour risk (e.g., known p53 mutations, familial cancer syndromes)