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To shed light on the aforementioned questions and more, we spoke with 2 clinicians: Nancy Bono, DO, chair of family medicine at New York Institute of Technology College of Osteopathic Medicine (NYITCOM), and Eleanor Yusupov, DO, assistant professor of clinical specialties at NYITCOM
Our Take Your body's ability to produce nitric oxide drops by as much as 50% by the time you hit 40
One study found that semaglutide can lead to an average 15% weight loss in a little over a year
Wegovy has shown the largest average weight loss in clinical trials
The package includes your medication, supplies (syringes and needles for injectables), and injection instructions
This suggests that while pharmacotherapy amplifies initial outcomes, structured exercise is strongly associated with more durable weight-loss maintenance
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