Antioxidants are substances that prevent or slow the damage that can be caused to cells by free radicals, which are also known as reactive oxygen species
Thus, it is plausible to use AOX in an endeavor to optimize the outcome of ICSI
FSH signaling is critical for the proliferation and functional maintenance of Sertoli cells: not only does it act synergistically with testosterone to preserve the structural integrity of the blood-testis barrier (BTB), but it also promotes lactate production by Sertoli cells, supplying crucial energy metabolic substrates for spermatogenic cells, thereby safeguarding the metabolic homeostasis of the spermatogenic microenvironment (137145)
This is crucial in wound healing, as improved blood flow supports tissue regeneration by delivering oxygen and nutrients to the damaged area
Moreover, elevated GSH levels can protect tumor cells by reducing the cytotoxic effects of several chemotherapy drugs, including cisplatin, doxorubicin, melphalan, and paclitaxel, ultimately leading to drug resistance [17]
Glutathione, also referred to as GSH, is a tripeptide composed of three amino acids: cysteine, glycine, and glutamic acid