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Additionally, metformin has been shown to modulate the MAPK signaling pathway, further contributing to its cardioprotective effects [180]

Comparison with the binding modes of other dual and triple agonists highlight that the N-terminal and C-terminal regions of the peptide confer receptor selectivity, whereas the middle region offers opportunities for sequence optimization to refine receptor engagement, thereby presenting a useful template for designing better unimolecular therapeutics

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