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Furthermore, phase 3 trials for GLP-2 analogs, such as glepaglutide and apraglutide, are ongoing for short bowel syndrome (114) and intestinal healing (115, 116)

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These non-scale wins often appear before the most dramatic weight drops and keep motivation high

Research has shown that: Weight regain often occurs if semaglutide is discontinued, with most patients regaining two-thirds of their lost weight within a year Long-term use may be necessary for maintaining weight loss, similar to treatments for other chronic conditions Regular monitoring by healthcare providers helps identify and address any concerns Five-year safety data now becoming available continues to support the medications favorable risk-benefit profile The FDA continues post-marketing surveillance of semaglutide to identify any rare adverse events that might not have been detected in clinical trials

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