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Lyophilised shelf life is up to 24 months when stored correctly
Acetaminophen in doses above 2g/day (saturates sulfation and glucuronidation, depletes glutathione catastrophically) R Alcohol (depletes glutathione, NAD+, SAM-e, and directly damages hepatocytes) R Charcoal-grilled meats (heterocyclic amines that undergo bioactivation via sulfation and acetylation, generating DNA-reactive intermediates) R Chronic NSAID use (competes for glucuronidation and amino acid conjugation pathways) Excess fructose (depletes ATP and drives uric acid production, impairing energy-dependent conjugation) R Glyphosate residues on non-organic produce (disrupts glycine metabolism and chelates manganese) R High-dose turmeric or quercetin without cycling (both inhibit SULT1A1 and can paradoxically impair sulfation at high sustained doses) R Processed foods with benzoate preservatives (benzoic acid consumes glycine through conjugation, depleting the glycine pool for other Phase II reactions) R Proton pump inhibitors chronically (reduce magnesium absorption, impair glucuronidation) R Testing These tests can help identify which conjugation pathways are impaired and what is contributing to the dysfunction
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However, once the methylester group of pectin is hydrolyzed, it also becomes more chemically accessible and thus more susceptible to degradation by microbial enzymes such as pectate lyase (PL) and polygalacturonase (PG), leading to loosening of the cell wall structure (Wormit and Usadel, 2018)
Sun Protection: While glutathione offers some protection against UV radiation, its crucial to continue using sunscreen to prevent further damage
Allows for 3 years shelf life & enhanced bio-availability
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