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Proposed Mechanisms Preventing GABA receptor downregulation Counteracting compensatory NMDA glutamate receptor sensitization Stabilizing benzodiazepine receptor configuration (preventing shift to inverse agonist state) Upregulating GABAergic neurotransmission through pathways distinct from benzodiazepine action itself This tolerance prevention has profound clinical implications

Drugs 74 , 929938 (2014)

10.1002/cpns.16 Curr

Fact: Response time varies widely, from a few days to several weeks depending on severity

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Liquid drops allow flexible dosing