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A sustained systolic increase of 10 mmHg or more from baseline while on CJC-1295 is clinically significant in a population where the ACC/AHA hypertension guideline already recommends a treatment threshold of 130/80 mmHg for adults with elevated cardiovascular risk [7]
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The manufacturer recommends discontinuing treatment if a patient is unable to tolerate the 2.4-mg dose
Patients experiencing significant hair shedding should discuss this with their prescribing clinician, who may recommend blood tests to exclude nutritional deficiencies (iron, B12, folate, zinc) or thyroid dysfunction as contributing factors
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