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Our studys findings suggest that all three drugs are fairly similar in terms of effectiveness and safety, says Derington, who is also a faculty member in the Adult and Child Center for Outcomes Research and Delivery Science

But it also means three sources of potential side effects, and a titration schedule that needs to account for all three receptor activations ramping up simultaneously

The background CV event rates from the placebo arms of previous RCTs with semaglutide were matched with the pre-adjudicated assumptions of the SOUL trial to create the predictive model

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In the liver and throughout the body, T4 is converted to T3