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CBS has been implicated in colorectal cancer carcinogenesis, its overexpression being detected even in precancerous lesions, such as hyperplastic polyps

Given the coupling between copper and energy status (e.g copper is a cofactor at Complex IV of the ETC) and how intensely metabolically active neurons are, it seems like short-term IP GHK-cu in the brain is acting analogously to the copper ionophore elesclomol in Tregs

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Moreover, high-salt diet (HSD), although not directly involving macronutrients, is noteworthy due to its potential impact on tumor biology

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