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All structural figures were generated using UCSF Chimera 99 , Chimera X 103 , and PyMOL (Schrdinger, LLC, Homology modeling of outward-facing ABCB7 The outward-facing conformation of human ABCB7 was modeled using the structure of human ABCB6 in the outward-open state (PDB ID 8K7C) as reference template 57

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I would nevertheless qualify the concept of Physiological Debt"