GIP (Glucose-Dependent Insulinotropic Polypeptide) Receptor: This receptor is also targeted by tirzepatide (Mounjaro, Zepbound)
Referral to cardiology is appropriate for patients with: Uncontrolled hypertension (160/100 mmHg) despite multiple medications Recent cardiovascular events (within 6 months) Symptomatic heart failure Complex arrhythmias Significant valvular disease Shared decision-making should incorporate discussion of expected weight loss magnitude, potential cardiovascular benefits including blood pressure reduction, common adverse effects (nausea, diarrhea, constipation), cost considerations, and the need for long-term treatment to maintain benefits
The neuronal mitochondrial dysfunction that follows a drop in estradiol levels in women causes insulin insensitivity and eventually brain insulin resistance to develop (16, 213, 214)
GLP-1 Receptor Agonists and the Thyroid: C-Cell Effects in Mice are Mediated via the GLP-1 Receptor and Not Associated With RET Activation
A prospective, randomized controlled trial is needed to confirm liraglutides efficacy as adjunct therapy after bariatric surgery
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