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The 24-mg dose cohort had the highest incidence of gastrointestinal events, possibly because of the higher starting dose (3 mg for 2 weeks) followed by the rapid dose escalation (weekly) until the maintenance dose was reached
Identification of N-terminally diversified GLP-1R agonists using saturation mutagenesis and chemical design
The Glutathione Response A robust Glutathione antioxidant response is needed to buffer rising ROS and prevent cellular damage
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