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Natural supplements are available that provide the building blocks for glutathione and may be helpful if you are deficient

Callahan HL, Crouch RK, James ER (1988) Helminth anti-oxidant enzymes: a protective mechanism against host oxidants

Glutathione (GSH) is the most abundant cellular non-protein thiol, attaining millimolar concentrations in the liver 6

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If the methylation process does not occur efficiently due to a lack of folate, the transsulfuration pathway will also be compromised, which in turn impairs the creation of glutathione