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Homocysteine and cardiovascular disease Observational studies indicate that even moderately elevated blood concentrations of homocysteine raise the risk of cardiovascular disease (CVD), although randomized controlled trials of homocysteine-lowering therapy have generally not translated to reductions in adverse cardiovascular outcomes (26, 27)

Median vitamin B12 levels before treatment were 328 (244429) pmol/l, and 973 (4761,476) pmol/l after treatment

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