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The addition of GSH or expression of Grxs 1 and 2 significantly improves mutant SOD1 solubility in cell culture, whereas reducing the levels of intracellular GSH decreases SOD1 solubility, suggesting that GSH reduction promotes the aggregation of mutant SOD1 (Guareschi et al., 2012)
What do preclinical timelines show
10.1111/jdi.12094 92
As a result of the intervention, reductions were observed in ASD symptoms such as social memory deficit, repetitive behaviors, and biomarkers of oxidative stress and apoptosis in the hippocampus [126]
Muscle carnitine efflux may be more important than its uptake during exercise
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