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STEP 1 and OASIS 4 were separate trials in different populations, so this is an indirect comparison rather than a head-to-head study but the overall efficacy signal is consistent across both

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Your genes largely determine how much melanin you produce, but sun exposure, hormones, and inflammation can also increase production and create darker spots or uneven tone

Li S, Lu MM, Zhou D, Hammes SR, Morrisey EE

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