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If semaglutide side effects disrupt your sleep (nausea, acid reflux when lying down), adjusting injection timing or taking an antacid before bed can help

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Indeed, tyrosine-972 in the NPEY motif of IR (numbering relative to human IR-B or +exon 11 isoform), which is phosphorylated following ligand stimulation, serves as a docking site for proteins with a PTB domain, such as IRS-1 and Shc, and mutation of this residue markedly decreases phosphorylation of these receptor substrates and activation of downstream signaling (16, 17)

Deenadayalan, S