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Metabolomic analyses from whole liver and isolated mitochondria using liquid chromatographymass spectrometry (LCMS) confirmed that heterozygosity for Slc25a51 was sufficient to lower the mitochondrial content of NAD + and multiple related metabolites (Fig

Second, the liver enzyme FMO3 normally neutralizes TMA

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While promising in vitro and in animal models, these systems remain largely experimental for human application

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