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Other documented findings include a tendency toward IGF-1 receptor desensitization with prolonged, continuous exposure, transient fluid retention in early study phases, and at supraphysiological exposure levels examined in some research acromegaly-like tissue changes

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Telomerase activation was reported in selected cultured human-cell experiments

After establishing a 5-day PCPA-induced insomnia model, treatments were administered over a subsequent 7-day period