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doi: 10.1016/S0140-6736(23)01185-6 106 PortronAJadidiSSarkarNDiMarchiRSchmittC

comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site

Further, active forms of GLP-1, as well as inactive metabolites, are rapidly eliminated by the kidneys ( The short half-life of endogenous GLP-1 has led to the development of GLP-1 receptor agonists (GLP-1RAs) and DPP-4 inhibitors as therapeutic strategies to extend the duration of GLP-1 action in the treatment of type 2 diabetes ( GLP-1 receptor agonists The first approved GLP-1 receptor agonist (GLP-1 RA) was exenatide in the United States of America (USA) in 2005 and in Europe one year later

While these findings are promising, they should not be interpreted as proof of effectiveness in humans

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No significant difference in overall effect size was shown after removing each study using sensitivity analysis