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(113), who demonstrated that in hepatocellular carcinoma (HCC), inhibition of HSP90 significantly promotes the ubiquitination and degradation of the highly expressed RNA polymerase II-associated protein 2 (RPAP2) via the CRL5-FBXW7 E3 ligase complex, thereby suppressing HCC cell proliferation

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The Lancet (2023) Phase 2 type 2 diabetes results Frias JP, et al

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