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B12 shots are given in the deltoid or gluteal muscle

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We typically start low, go slow, and pair folate with the right B12 form (often methylcobalamin, sometimes adenosyl- or hydroxocobalamin) while tracking symptoms and labs

The hallmark symptom is stabbing pain near the heel, particularly intense with the first steps after waking or after prolonged periods of sitting

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In vitro studies have characterised its effects on antioxidant enzyme expression profiles and melatonin biosynthesis pathway regulatory mechanisms in cell line models