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Overexpression of IRP2 or MPP + treatment significantly enhances the binding of IRP2 to p53 in PC-12 cells, upregulates p53 levels, downregulates SLC7A11 expression, and increases arachidonate 12-Lipoxygenase (ALOX12) expression, thereby promoting ferroptosis and amino acid antioxidant system disruptions, elevating MDA levels, and inducing PC-12 cell damage

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Mulberry fruit ameliorates Parkinsons-disease-related pathology by reducing alpha-synuclein and ubiquitin levels in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model

The VH is linked distal to the VL (kappa) by a 3-time repeated G4S linker and then genetic codes are optimized for the mouse species

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