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GSTs are able to conjugate glutathione (-l-glutamyl-l-cysteinyl-glycine, GSH) to a wide range of hydrophobic and electrophilic molecules including many carcinogens, therapeutic drugs, and many products of oxidative metabolism, making them less toxic and predisposed to further modification for discharge from the cell (Fig

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Findings in rodents have led to the evaluation of several therapeutic approaches targeted at boosting levels of SOD and/or GPX1 or the use of low molecular weight mimetics to suppress excess ROS in beta cell lines and experimental animals afflicted with various pathologies (Bertera et al

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2535% by de novo lipogenesis (DNL) in the liver