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Large, randomized controlled trials (RCTs) provide the most robust evidence

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For context, in one study of 175 people with overweight or obesity, participants taking semaglutide: Lost an average of 15 pounds (about 6% of their body weight) within three months Lost an average of 27 pounds (about 11% of their body weight) after six months Recommended lifestyle changes during GLP-1 therapy GLP-1 medications can boost weight loss by increasing satiety and reducing food cravings

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It takes approximately four to five weeks of consistent weekly dosing for semaglutide to reach what researchers call steady-state concentration in your bloodstream

Moreover, the gut-selective dose of sitagliptin was unable to lower TG excursion in HFD-fed Dpp4 EC+/+ and Dpp4 EC/ mice, before and after BMT, despite an approximately 20% reduction in plasma DPP-4 activity and an increase in active GLP-1 (Figure 7)