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Tex Heart Inst J 18(1):41 Bogle C, Colan SD, Miyamoto SD, Choudhry S, Baez-Hernandez N, Brickler MM, Feingold B, Lal AK, Lee TM, Canter CE, Lipshultz SE (2023) Treatment strategies for cardiomyopathy in children: a scientific statement from the American Heart Association

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Among them, oxidative damage to the autonomic nervous system due to iron accumulation associated with diabetes may be due to changes in the NRF2-GPX4 pathway in ferroptosis (113, 114), the transcription factor that regulates SLC7A11 (51) can effectively prevent oxidative damage in various pathological conditions upon NRF2 activation (115, 116)

(PubMed) Cardoso BR, Braat S, Graham RM

OH can react with metals like Fe (already present in the cytosol) to start a chain of oxidation reaction and the subsequent generation of ROS, resulting from the Fenton reaction, leads to cellular damage (Hasan et al., 2024)

GLP-1 improves adipocyte insulin sensitivity following induction of endoplasmic reticulum stress