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doi: 10.3389/fmed.2020.00170 72 VioliF.LoffredoL.CarnevaleR.PignatelliP.PastoriD

General best-practice guidance consistent with NHS and professional body recommendations supports regular resistance exercise and adequate dietary protein intake to help preserve muscle tissue during weight management

This randomized, double-blind, placebo-controlled trial in 58 older adults identified as "pre-frail" found an decrease in a Frailty Index score and an improvement in the hand grip test in individuals supplemented with L-carnitine (1.5 g/day) over 10 weeks but not in those given a placebo (118)

(Reference: Rubino et al., Diabetes Care, 2021) Yes

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