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For a patient population already managing stress physiology and body composition, avoiding unnecessary cortisol elevation matters
However, these mainstream therapies face critical limitations including the rapid emergence of drug resistance, FKS1/FKS2 gene mutations reducing -1,3-glucan synthase affinity, Targeted enzyme (Erg11p) modification, overexpression of efflux pumps (CDR1, MDR1), and upregulation of the ergosterol pathway mediate azole resistance (Pristov and Ghannoum, 2019)
J Biol Chem 280:2530525312 Knollema S, Hom HW, Schirmer H, Korf J, Ter Horst GJ (1996) Immunolocalization of glutathione reductase in the murine brain
Se ha demostrado que los sistemas de administracin liposomales producen efectos ms inmediatos y concentraciones plasmticas ms estables
15 CostabileA.ButtarazziI.KolidaS.QuerciaS.BaldiniJ.SwannJ
PMID 15012235
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