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In contrast, GCLC inhibition exerted a minimal impact on the growth of PDX tumors with low ACTL6A expression (cases 2 and 4) tumors (Fig

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Consequently, this leads to a loss of skin color in the affected regions, resulting in conspicuous pale spots ranging in size from a few millimeters to several centimeters (169)

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However, results plateaued after week 10, suggesting receptor saturation or limited penetration