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In a pre- and postnatal development study in pregnant cynomolgus monkeys, subcutaneous doses of 0.015, 0.075, and 0.15 mg/kg twice weekly (0.3-, 2-, and 4-fold the MRHD) were administered from Gestation Day 16 to 140

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Thiacremonone pretreatment significantly decreases the levels of the above cytokines and increases the expression of IL-1RA (interleukin-1 receptor antagonist), CXCL2, and CXCL10, thus alleviating AILI [210]

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