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They intended to follow patients for 24 weeks but due to the COVID-19 pandemic, this was not possible

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First in the methionine synthase reaction, homocysteine is converted to methionine allowing for the recycling of 5-methyl-tetrahydrofolate (THF) to N5,10 methylene-THF which is needed for the de novo synthesis of thymidylic acid and ultimately, for DNA formation