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Retatrutide Who Should NOT Use It Contraindications (Based on Research & Trial Exclusions) 1) Personal/family history of medullary thyroid carcinoma (MTC) or MEN2 Similar medications in the GLP-1 receptor agonist class list this as a contraindication due to observed thyroid C-cell tumors in rodent studies and exclusion from trials

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Aging 1 , 165178 (2021)

Decreased tNAA and increased Glx at 6 months were significantly associated with higher cognitive symptoms at 6 months, but the associations were small (r = 0.072, 0.179 respectively)

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Long-term safety considerations remain important for both agents