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Clin Exp Health Sci 13(4):753759 Ding D, Liu H, Qi W, Jiang H, Li Y, Wu X, Sun H, Gross K, Salvi R (2016) Ototoxic effects and mechanisms of loop diuretics

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[7] These medications have also been linked to improvements in blood pressure and cholesterol levels, enhancing overall metabolic health and potentially reducing the risk of heart failure and kidney disease

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It's always wise to begin research with a conservative, well-established protocol and adjust only when necessary