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As evaluated by MR scans, the sub-study showed all three doses of tirzepatide (5 mg, 10 mg, 15 mg) led to greater reductions in liver fat content compared to insulin degludec, and reductions in volume of visceral adipose tissue and abdominal subcutaneous adipose tissue compared to increases in volume of both measurements with insulin degludec at 52 weeks
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The issue of obesity and insulin resistance prompted the design of a number of studies investigating the effects of antidiabetic drugs in PCOS, as reported in recent and very exhaustive reviews on the available clinical trials on glucagon-like peptide 1 receptor agonists (GLP-1RA) in PCOS [21, 23, 24]
Circulating autoantibodies may also have a major role in the manifestation of long-term fatigue in PASC patients 644
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