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Methylation burden & metabolic dysfunction research: Laboratory applications in cellular methylation stress, SAM-cycle imbalance and NAD+ salvage engineering

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(2021, May 12)

PMCID: PMC5551541

31 Less commonly, hyperthyroidism is caused by conditions other than Graves disease, including toxic multinodular goiter, in which non-cancerous growths in the thyroid cause the gland to swell and make too much T4

We found that Dihexa-mediated protection requires activation of Akt, TOR, and MEK signaling, as inhibition of any of these targets attenuates Dihexa-mediated protection