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The upregulation of interferon-stimulated gene 15 in TECs disrupted mitochondrial homeostasis and triggered the release of mtDNA into the cytosol, which then triggers NLRP3mediated pyroptosis in cyclic GMP-AMP synthase-stimulator of interferon genes pathway (47)

From ubiquinol, the electrons pass down the redox gradient through complex III (coenzyme Q-cytochrome c oxidoreductase) to cytochrome c , then to complex IV (cytochrome c oxidase) and to the final acceptor, oxygen (O 2 ) to produce water