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Through the inhibition of phosphoinositide 3-kinase (PI3K), 3-MA disrupts the formation of autophagosomes, thereby impeding the initiation of the autophagic process

J Am Chem Soc 141:52755285 Takusagawa S, Satoh Y, Ohtsu I, Dairi T (2019) Ergothioneine production with Aspergillus oryzae

The close proximity of the POI and the E3 ligase leads to the ubiquitination of the substrate, followed by proteasomal degradation 33

Furthermore, evidence for changes in the level of blood or tissue mitochondrial function or metabolic readouts is currently lacking for these studies

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