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doi.org/10.1113/jphysiol.2012.244897 Escobar, K

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Cardiovascular outcomes studies confirmed reduced major adverse events in patients with existing cardiovascular disease

Understanding that weight maintenance requires ongoing treatment Clinical data consistently shows that stopping GLP-1 medications leads to significant weight regain for most people

Significant results are often observed over a period of 3 to 6 months, depending on consistent adherence to the prescribed regimen, along with lifestyle modifications

However, tirzepatide significantly lowers blood sugar, so other diabetes medications, especially insulin and sulfonylureas, often need dosage reduction to prevent hypoglycemia